Expressional Analysis and Role of Calcium Regulated Kin ...
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Expressional Analysis and Role ...
Perception of stimuli and activation of a signaling cascade is an intrinsic characteristic feature of all living organisms. Till date, several signal ...
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Cautionary Tail: The Presence o ...
As part of structural investigations of components of the molecular motor, dynein, we prepared the light chain, Robl1_mouse, with and without an N-te ...
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Gene Expression Profiling and i ...
The availability of sequenced genomes of human and many experimental animals necessitated the development of new technologies and powerful computatio ...
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The Role of Androgen Receptor M ...
Prostate tumour growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signalling axis are u ...
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Recent Computational Approaches ...
This paper reviews recent computational approaches to the understanding of gene regulation in eukaryotes. Cis-regulation of gene expression by the bi ...
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The Human Glioma-Associated Onc ...
Sonic hedgehog (Shh) signaling is critically important for embryogenesis and other cellular processes in which GLI transcription factors mediate the ...
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H2A.Z-Mediated Genome-Wide Chro ...
The characterization of the involvement of different histone post-translational modifications (PTMs) and histone variants in chromatin structure has ...
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Myostatin in the Pathophysiolog ...
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved acr ...
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Molecular Pathophysiology of Re ...
Renal tubular acidosis (RTA) is characterized by metabolic acidosis due to renal impaired acid excretion. Hyperchloremic acidosis with normal anion g ...
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The C Terminus of p53 Family Pr ...
The p53 tumor suppressor is the most commonly mutated gene in human cancers. The ability of p53 to induce cell cycle arrest, apoptosis, DNA repair, a ...
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Genetic and Environmental Facto ...
Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addic ...
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Designing the Optimal Vaccine: ...
Many vaccines existing today provide strong protection against a wide variety of infectious organisms, and these consist of either live attenuated or ...
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Megsin Gene: Its Genomic Analys ...
It is critical to uncover genes specifically expressed in individual cell types for further understanding of cell biology and pathology. In order to ...
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Zebrafish as a Model System to ...
Zebrafish (Danio rerio) is a bona fide vertebrate model system for understanding human diseases. It allows the transparent visualization of the effec ...
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Pas de deux: Natural Killer Rec ...
Major histocompatibility complex (MHC) class I and NK cell receptor gene regions are a paradigm of genomic plasticity as they reveal a considerable d ...
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Challenges and Solutions in Pro ...
The accelerated growth of proteomics data presents both opportunities and challenges. Large-scale proteomic profiling of biological samples such as c ...
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Mechanisms and Signals for the ...
In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytopla ...
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How Many Mutant p53 Molecules A ...
The tumor suppressor p53 is transcription factor composed of four identical subunits. The majority of the mutations in p53 are missense mutations tha ...
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Advances in Genetical Genomics ...
Natural variation provides a valuable resource to study the genetic regulation of quantitative traits. In quantitative trait locus (QTL) analyses thi ...
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Gain-of-Function Mutations of R ...
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in human gastrointestinal tract. We first found that most GISTs expres ...
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Patterns of Insertion and Delet ...
Nucleotide insertions and deletions (indels) are responsible for gaps in the sequence alignments. Indel is one of the major sources of evolutionary c ...
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Cytosine Methyltransferases as ...
Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and ...
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Functional Annotation of Genes ...
We have used Gene Ontology (GO) and pathway analyses to uncover the common functions associated to the genes overlapping Copy Number Variants (CNVs) ...
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A rapid and specific PCR–ELISA ...
Background: Salmonella continues to be a major food borne pathogen for animals and humans. A sensitive and specific PCR–ELISA technique was developed ...
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INVESTIGATION OF DEEP STERNAL W ...
Objective: To investigate factors that predict sternal wound complications in patients after coronary artery bypass grafting (CABG) because predictio ...
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