The Arrestin Fold: Variations o ...
Endocytosis of ligand-activated plasma membrane receptors has been shown to contribute to the regulation of their downstream signaling. ..-arrestins ...
Improving the potency of DNA va ...
Background: Studies have shown that the VP22 gene of Marek’s Disease Virus type-1 (MDV-1) has the property of movement between cells from the origina ...
Dendritic Cells and Macrophages ...
Dendritic cells (DCs) and macrophages differently contribute to the generation of coordinated immune system responses against infectious agents. They ...
Accessibility Control of Recomb ...
During B cell development, two somatic DNA recombination events occur at the immunoglobulin heavy chain loci: VDJ recombination and class switch reco ...
A Systematic Review of Meta-Ana ...
Background. Individual variations in gastric cancer risk have been associated in the last decade with specific variant alleles of different genes tha ...
The MTT [3-(4,5-Dimethylthiazol ...
The entomopathogenic fungus Neozygites parvispora (Entomophthorales: Zygomycetes) grows in vitro as irregularly rod-shaped hyphal bodies in a complex ...
Toxicogenomics to Improve Compr ...
Engineered nanomaterials are commonly defined as materials with at least one dimension of 100 nanometers or less. Such materials typically possess na ...
Rallying the Troops: Innate Muc ...
The mucosal surfaces of the gastrointestinal tract are constantly exposed to large quantities of commensal microbes and enteric pathogens. Highly sop ...
Estrogen Regulation of MicroRNA ...
Women outlive men, but life expectancy is not influenced by hormone replacement (estrogen + progestin) therapy. Estrogens appear to protect brain, ca ...
Nutrigenomic Analysis of Diet-G ...
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nut ...
Beyond Stressed Self: Evidence ...
The activity of cytotoxic lymphocytes is regulated by the opposing function of stimulatory and inhibitory cell surface receptors. According to the no ...
Recent Advances in the Characte ...
Human resistance to infection by schistosomes is associated to a strong Th2 immune. However a persistent Th2 response can cause severe kidney and liv ...
Molecular Mechanisms of Inherit ...
Inherited arrhythmias and conduction system diseases are known causes of sudden cardiac death and are responsible for significant mortality and morbi ...
Cloning and characterization of ...
Background: The CHD7 (Chromodomain Helicase DNA binding protein 7) gene encodes a member of the chromodomain family of ATP-dependent chromatin remode ...
Analysis of NCL Proteins from a ...
The Neuronal Ceroid Lipofuscinoses (NCLs) are the most common group of neurodegenerative disorders of childhood. While mutations in eight different g ...
Alternative Splicing and Tumor ...
Alternative splicing is a key molecular mechanism for increasing the functional diversity of the eukaryotic proteomes. A large body of experimental d ...
Application of TILLING and EcoT ...
With the fairly recent advent of inexpensive, rapid sequencing technologies that continue to improve sequencing efficiency and accuracy, many species ...
IgG4-Related Disease (IgG4+MOLP ...
Since the first report on patients with elevated serum IgG4 in sclerosing pancreatitis in 2001, various systemic disorders, described by many names, ...
Saturation of the Human Phenome
The phenome is the complete set of phenotypes resulting from genetic variation in populations of an organism. Saturation of a phenome implies the ide ...
Salivary Genomics, Transcriptom ...
There is an increasingly growing interest world-wide for the genomics, transcriptomics and proteomics of saliva and the oral cavity, since they provi ...
Periostin as a Heterofunctional ...
Periostin (Postn) is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesi ...
Clinical, Molecular, and Geneti ...
PAPA syndrome (Pyogenic Arthritis, Pyoderma gangrenosum, and Acne) is an autosomal dominant, hereditary auto-inflammatory disease arising from mutati ...
Genetics and Molecular Biology ...
Tuberous Sclerosis Complex is a multisystem disorder exhibiting a wide range of manifestations characterized by tumour-like lesions called hamartomas ...
MicroRNA: Implications for Alzh ...
Understanding complex diseases such as sporadic Alzheimer disease (AD) has been a major challenge. Unlike the familial forms of AD, the genetic and e ...
Epigenetic Control of MicroRNA ...
MicroRNAs are a major category among the noncoding RNA fraction that negatively regulate gene expression at the post-transcriptional level, by either ...