Endometrial Cancer as a Familial Tumor: Pathology and M ...
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Endometrial Cancer as a Familia ...
Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lync ...
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Control of the Bone Morphogenet ...
The TGF.. superfamily growth factor BMP7 performs essential biological functions in embryonic development and regeneration of injured tissue in the a ...
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Modeling the Genetic Control of ...
The progression of HIV disease has been markedly slowed by the use of highly active antiretroviral therapy (HAART). However, substantial genetic vari ...
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NBS1 Heterozygosity and Cancer ...
Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by c ...
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Comprehensive Resources for Tom ...
Tomato (Solanum lycopersicum L., Solanaceae) is an excellent model plant for genomic research of solanaceous plants, as well as for studying the deve ...
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Genomic Organization and Contro ...
Grb7 and their related family members Grb10 and Grb14 are adaptor proteins, which participate in the functionality of multiple signal transduction pa ...
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Gene therapy: Regulations, ethi ...
Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to t ...
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The Role of Major Histocompatib ...
Major histocompatibility complex (MHC) genes are involved in various mechanisms of pathogenesis and immunoediting of non-Hodgkin’s lymphoma (NHL). MH ...
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An Outlook on Ovarian Cancer an ...
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease- ...
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Analysis of the Fragile X Trinu ...
Fragile X Syndrome (FXS) is associated with an unstable CGG repeat sequence in the 5’ untranslated region in the first exon of the FMR1 gene which re ...
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Clinical Proteomics of Breast C ...
Despite the lifetimes that increased in breast cancers due to the the early screening programs and new therapeutic strategies, many cases still are b ...
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The Genomics of Colorectal Canc ...
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a step ...
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Combating Bacterial Pathogens T ...
Antibiotic resistance, bioterrorism and microbial induced autoimmune disorders have made bacterial infections a growing concern in our society. To co ...
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Pan-Vertebrate Toll-Like Recept ...
Human toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) to raise innate immune responses. The human TLR family was ...
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Toll-Like Receptor Signaling: E ...
The family of Toll-like receptors (TLR1-TLR11) provides host defense in mammals by inducing proinflammatory innate immune response upon recognition o ...
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A Survey of Chloroplast Protein ...
Protein phosphorylation is a major mode of regulation of metabolism, gene expression and cell architecture. In chloroplasts, reversible phosphorylati ...
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Translational Science: Epistemo ...
The term “translational science” has recently become very popular with its usage appearing to be almost exclusively related to medicine, in particula ...
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Peripheral Tolerization of Effe ...
Due to the random generation of T cell antigen receptors, a large fraction of developing T cells have the potential to recognize self-determinants. T ...
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OX40:OX40L Axis: Emerging Targe ...
Recent advances in our understanding of the mechanisms through which T cells are activated have led to new therapeutic approaches in the treatment of ...
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Coordination of Ribosomal Prote ...
Cells grow in response to nutrients or growth factors, whose presence is detected and communicated by elaborate signaling pathways. Protein kinases p ...
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The Epigenetic Origin of Aneupl ...
Theodore Boveri, eminent German pathologist, observed aneuploidy in cancer cells more than a century ago and suggested that cancer cells derived from ...
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Molecular Genetics of Alcohol D ...
Alcohol dependence is a worldwide public health problem, and involves both environmental and genetic vulnerability factors. The heritability of alcoh ...
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Dihydrofolate Reductase Gene Va ...
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent e ...
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Array-Based Approaches for the ...
Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of ...
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Gene Expression Profiling as a ...
The identification of quantitative trait loci, QTL, in arthritis animal models is a straight forward process. However, to identify the underlying gen ...
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