Clinical Trials for Acute Kidney Injury: Design Challen ...
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Drug-Binding Databases
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Clinical Trials for Acute Kidne ...
Acute kidney injury is associated with significant morbidity and mortality in hospitalized patients. Clinical trials for acute kidney injury have bee ...
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Coenzyme Q10 in Neuromuscular a ...
Coenzyme Q10 (CoQ10, or ubiquinone) is an electron carrier of the mitochondrial respiratory chain (electron transport chain) with antioxidant propert ...
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Colloidal and Pharmacological A ...
Human albumin is extensively used and investigated in clinical fluid management. Whether albumin confers sufficient benefit to justify its cost has b ...
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Comparative Antioxidant Level i ...
In order to investigate the protective role of cefepime plus amikacin (Potentox) reconstituted with solvent for injection vs cefepime and amikacin al ...
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Cloning and expression of a reg ...
An assay for the endopeptidase activities of clostridial neurotoxins in contaminated biotherapeutic products has been developed. Based on a synthetic ...
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Computational Methods for Calcu ...
Precise computational methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inte ...
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Current Advances in the Develop ...
Protein kinases, either membrane-embedded receptorial or cytosolic non-receptorial ones, are important transducers of cell proliferation signals. In ...
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Current Status of Therapeutic A ...
Therapeutic angiogenesis, stimulated growth of new vasculature to compensate for tissue ischemia, has been studied in a number of clinical trials in ...
207.98 KB
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Drug-Binding Databases
Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. Th ...
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Effective Anticancer Drug and F ...
This review addresses mainly the polyamine levels in various tissues and regional brain of (intact) rats treated with various types of anticancer dru ...
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Emerging Drug Candidates of Dip ...
Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones, glucagon-like peptide (GLP-1) and glucose-dependent insulinotrop ...
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Emerging Therapies for Type 2 D ...
Type 2 diabetes results from progressive ..-cell dysfunction and insulin resistance, leading to progressive worsening of glycemic control, and increa ...
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Epidemiology of Septic Acute Ki ...
The incidence of sepsis and acute kidney injury (AKI) is increasing in critically ill patients and both portend a higher risk of morbidity and death. ...
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Epidermal Growth Factor Recepto ...
A number of cancer chemotherapeutics targeting the epidermal growth factor receptor (EGFR) are in development. These compounds were designed to eithe ...
172.08 KB
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Evaluation of Molecular Docking ...
Molecular docking simulations are of pivotal importance for analysis of protein-ligand interactions and also an essential resource for virtual-screen ...
476.54 KB
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Cloning, high level expression ...
Botulinum neurotoxins (BoNTs) inhibit neurotransmitter release from peripheral cholinergic synapses. BoNTs consist of a toxifying light chain and a h ...
331.90 KB
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Experimental Approaches to Eval ...
Precise experimental methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inter ...
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Genetically Modified Hepatitis ...
The surface antigen of hepatitis B virus (HBsAg) spontaneously aggregates into ‘empty’ virus-like particles (VLPs) in the absence of other viral comp ...
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GSK3 at the Edge: Regulation of ...
GSK3 is a multifunctional protein kinase that is pivotal for the regulation of metabolism, the cytoskeleton, and gene expression. Multicellular eukar ...
513.75 KB
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Heme Oxygenase-1 in Tumor Biolo ...
Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous iron. As HO-1 expression is highly increased by stressful cond ...
919.20 KB
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Hepatitis B and Liver Transplan ...
Liver transplantation was approved for the treatment of decompensated cirrhosis in the United States in 1983. Hepatitis B and hepatitis C viruses are ...
167.34 KB
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HIV: A Raft-Targeting Approach ...
It has been widely accepted that HIV-1 enters into and buds out from microdomains known as lipid rafts/caveolae of plasma membranes of infected cells ...
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HIV Management: New Approaches
Development of resistance towards currently used anti-HIV drugs is an important determinant in the classical drug failure. Mutations located in the e ...
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Human Leptin Regulation and Pro ...
In rodents leptin inhibits food intake, stimulates energy expenditure, reverses obesity, ameliorates insulin resistance, and accelerates sexual matur ...
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Ibopamine Stimulates ..-Adrener ...
Ibopamine stimulates ..-adrenergic receptors and D1-dopaminergic receptors in the eye. Ibopamine is a dopamine analogue and it is hydrolysed to epini ...
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