Pathogenesis of Acute Kidney Injury During Sepsis
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Pathogenesis of Acute Kidney In ...
Septic acute kidney injury (AKI) occurs between 15% and 20% of all intensive care unit admissions and its mortality ranges from 20% to 60%. The incid ...
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Pathophysiology of Sepsis in th ...
The aging world population will increase the incidence and mortality of severe sepsis. The aim of the present article is to review the pathophysiolog ...
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PDGF-D Signaling: A Novel Targe ...
Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation ...
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Pemetrexed: Potential Role in t ...
Platinum-based doublet chemotherapy is now established as a standard of care in the adjuvant treatment of resected stage II and stage IIIA nonsmall c ...
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Pharmacological Aspects of the ...
Conventional regimens have limited impact against NSCLC. Current research is focusing on multiple pathways as potential targets, and this review desc ...
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Predictive Markers for Haematol ...
Pemetrexed is a multi-targeted anti metabolite that inhibits several key folate-dependent enzymes in the thymidine and purine biosynthetic pathways, ...
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Protein Crystallography in Drug ...
Protein crystallography is the main technique used to obtain three-dimensional information for binary complexes involving protein and drugs. Once a p ...
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Role of ARBs in the Blood Hyper ...
Hypertension has a worldwide high incidence in the general population and undoubtedly it is the most important risk factor for cardiovascular morbidi ...
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Miliary tuberculosis with empye ...
We report a 39 year-old patient who presented with chest pain, malaise, lassitude, anorexia, weight loss, fever, chills, productive coughs, pleural p ...
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Should Adipokines be Considered ...
White adipose tissue (WAT) is an important endocrine organ that secretes approximately 30 biologically active peptides and proteins, collectively ter ...
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Sphingomyelinase Inhibition Sug ...
Multiple lines of evidence suggest that macrophages have a critical role in the disease pathology of inflammatory bowel disease (IBD) by secreting in ...
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Targeted Elimination of Leukemi ...
Despite recent advances, treatment of leukemia is often not curative. New insights indicate that this may be attributable to a small population of th ...
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Targeting Karyotypic Complexity ...
Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemothera ...
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Targeting Matrix Metalloprotein ...
The matrix metalloproteinases (MMPs) and their endogenous regulators, the tissue inhibitors of MMPs (TIMPs) are responsible for the physiological rem ...
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Targeting the Expression of Ant ...
Antisense oligonucleotide (ASO) biotechnology has been widely used to inhibit the expression of proteins involved in human disease. ASOs are designed ...
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The Bioartificial Kidney in the ...
Acute kidney injury (AKI) continues to have an exceedingly high mortality rate, despite advances in dialysis technology. Current dialysis therapies r ...
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The Macrophage Stimulating Prot ...
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several import ...
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The Molecular Mechanisms of Glu ...
Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bro ...
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The Role of Chemotherapy and Ra ...
Approximately one out of every three patients with non-small cell lung cancer (NSCLC) has locally advanced disease that is surgically unresectable. I ...
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Japanese Encephalitis: Epidemio ...
Japanese encephalitis is a major cause of encephalitis in Asia. An estimated 50 000 cases occur in largely rural areas of the south and east Asian re ...
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Gene finding in the chicken gen ...
Background: Despite the continuous production of genome sequence for a number of organisms, reliable, comprehensive, and cost effective gene predicti ...
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The Role of Pemetrexed in Advan ...
Pemetrexed is a newer antifolate drug that has been approved as first-line treatment for patients with advanced non-squamous, non-small cell lung can ...
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The Role of Pemetrexed in Lung ...
Bronchioloalveolar carcinoma (BAC) and adenocarcinoma with bronchioloalveolar features (ADC-WBF) belong to the same anatomo-clinical entity and show ...
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Therapy and Further Development ...
Leishmaniasis is a parasitic infection that affects millions of people worldwide, especially in tropical and subtropical areas, and is responsible fo ...
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Transdermal Penetration Enhance ...
Transdermal drug therapy has been one of the major research fields in the area of drug therapy for last few decades. However inspite of its large the ...
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