Who’s Winning the War? Molecular Mechanisms of Antibiot ...
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Molecular Docking Algorithms
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Drug-Binding Databases
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Cause of Chirality Consensus
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Who’s Winning the War? Molecula ...
The ability of clinicians to wage an effective war against many bacterial infections is increasingly being hampered by skyrocketing rates of antibiot ...
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Therapy and Further Development ...
Leishmaniasis is a parasitic infection that affects millions of people worldwide, especially in tropical and subtropical areas, and is responsible fo ...
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Japanese Encephalitis: Epidemio ...
Japanese encephalitis is a major cause of encephalitis in Asia. An estimated 50 000 cases occur in largely rural areas of the south and east Asian re ...
1.81 MB
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Sphingomyelinase Inhibition Sug ...
Multiple lines of evidence suggest that macrophages have a critical role in the disease pathology of inflammatory bowel disease (IBD) by secreting in ...
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Protein Crystallography in Drug ...
Protein crystallography is the main technique used to obtain three-dimensional information for binary complexes involving protein and drugs. Once a p ...
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New Targets for Therapy in Poly ...
The polyglutamine (polyQ) repeat disorders are a family of inherited disorders characterized by progressive neurodegeneration, as well as the formati ...
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Nanogel Engineered Polymeric Mi ...
In the past few decades nanotechnology for drug delivery has attracted a great deal of attention. Nanogels under this category are sub-micron sized w ...
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Molecular Modeling as a Tool fo ...
With the progression of structural genomics projects, comparative modeling remains an increasingly important method of choice to obtain 3D structure ...
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Molecular Docking Algorithms
By means of virtual screening of small molecules databases it is possible to identify new potential inhibitors against a target of interest. Molecula ...
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Metabotropic Glutamate Receptor ...
Multiple in vivo and in vitro studies show that excessive release of glutamate, and subsequent activation of ionotropic glutamate receptors (iGluRs) ...
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Linear Interaction Energy (LIE) ...
Currently, in order to accelerate the process of drug development and also reduce costs, many of the experimental assays related to lead discovery an ...
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In Silico and In Vitro: Identif ...
Drug development is a high cost and laborious process, requiring a number of tests until a drug is made available in the market. Therefore, the use o ...
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Genetically Modified Hepatitis ...
The surface antigen of hepatitis B virus (HBsAg) spontaneously aggregates into ‘empty’ virus-like particles (VLPs) in the absence of other viral comp ...
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Experimental Approaches to Eval ...
Precise experimental methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inter ...
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Evaluation of Molecular Docking ...
Molecular docking simulations are of pivotal importance for analysis of protein-ligand interactions and also an essential resource for virtual-screen ...
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Drug-Binding Databases
Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. Th ...
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Current Advances in the Develop ...
Protein kinases, either membrane-embedded receptorial or cytosolic non-receptorial ones, are important transducers of cell proliferation signals. In ...
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Computational Methods for Calcu ...
Precise computational methods to determine ligand-binding affinity are needed to accelerate the discovery of new drugs. Assessing protein-ligand inte ...
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Synthesis, Characterisation, An ...
A facile synthesis and characterisation of novel dispiro-oxindolopyrrolidines is delineated. The results of the anti-microbial studies of novel dispi ...
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Chemical Biology: Past, Present ...
Chemical biology (CB) is a scientific discipline spanning the fields of chemistry and biology involving the application of chemical techniques and to ...
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Single Molecule Studies in Chem ...
Modern ultra-sensitive instrumental skill and expertise on surface modification of single biological molecules have sharpened the capabilities of sci ...
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Relationship Between Metal Tran ...
Trace elements as Cu (copper), Fe (iron), and Zn (zinc) can be toxic when their distribution is not carefully regulated, and also their inappropriate ...
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N-Terminal Specific Fluorescenc ...
The function of a protein correlates closely with its structure; even partial structural disorder/misfolding may lead to various diseases such as Par ...
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Enzymes with Phosphotriesterase ...
Organophosphates (OPs) are a class of synthetic compounds used both as pesticides and nerve agents. They are chemically phosphoesters and biologicall ...
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Cause of Chirality Consensus
Biological macromolecules, proteins and nucleic acids are composed exclusively of chirally pure monomers. The chirality consensus appears vital for l ...
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