Genetics in Osteoarthritis
Role of TARC/CCL17 and CTACK/CC ...
TARC/CCL17 is designated as a Th2 type chemokine since it binds to CCR4. CTACK/CCL27 is a ligand for CCR10 and is selectively expressed in skin. Atop ...
Haplotypes in SLC24A5 Gene as A ...
Ancestry informative markers (AIMs) are human polymorphisms that exhibit substantially allele frequency differences among populations. These markers ...
Cancer Metastasis as Disrupted ...
Cancer metastasis is a complex processes, associated with the invasion to tissues with extensive degradation of the surrounding normal components, pe ...
Simulation of Genomes: A Review
There is an increasing role of population genetics in human genetic research linking empirical observations with hypotheses about sequence variation ...
Genetics in Osteoarthritis
Osteoarthritis is a degenerative articular disease with complex pathogeny because diverse factors interact causing a process of deterioration of the ...
Internet Resources for Gene Exp ...
The number of online databases and web-tools for gene expression analysis in Arabidopsis thaliana has increased tremendously during the last years. T ...
Genomic Instability and Carcino ...
Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many canc ...
Gene Expression Profiling as a ...
The identification of quantitative trait loci, QTL, in arthritis animal models is a straight forward process. However, to identify the underlying gen ...
Array-Based Approaches for the ...
Carcinogenesis involves the inactivation or inhibition of genes that function as tumor suppressors. Deletions, mutations, or epigenetic silencing of ...
Molecular Genetics of Alcohol D ...
Alcohol dependence is a worldwide public health problem, and involves both environmental and genetic vulnerability factors. The heritability of alcoh ...
The Epigenetic Origin of Aneupl ...
Theodore Boveri, eminent German pathologist, observed aneuploidy in cancer cells more than a century ago and suggested that cancer cells derived from ...
A Survey of Chloroplast Protein ...
Protein phosphorylation is a major mode of regulation of metabolism, gene expression and cell architecture. In chloroplasts, reversible phosphorylati ...
Pan-Vertebrate Toll-Like Recept ...
Human toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) to raise innate immune responses. The human TLR family was ...
The Genomics of Colorectal Canc ...
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a step ...
Analysis of the Fragile X Trinu ...
Fragile X Syndrome (FXS) is associated with an unstable CGG repeat sequence in the 5’ untranslated region in the first exon of the FMR1 gene which re ...
Gene therapy: Regulations, ethi ...
Gene therapy is a new and promising approach which opens a new door to the treatment of human diseases. By direct transfer of genetic materials to t ...
Genomic Organization and Contro ...
Grb7 and their related family members Grb10 and Grb14 are adaptor proteins, which participate in the functionality of multiple signal transduction pa ...
Comprehensive Resources for Tom ...
Tomato (Solanum lycopersicum L., Solanaceae) is an excellent model plant for genomic research of solanaceous plants, as well as for studying the deve ...
NBS1 Heterozygosity and Cancer ...
Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by c ...
Modeling the Genetic Control of ...
The progression of HIV disease has been markedly slowed by the use of highly active antiretroviral therapy (HAART). However, substantial genetic vari ...
Haploinsufficiency of DNA Damag ...
Genomic disorders are a clinically diverse group of conditions caused by gain, loss or re-orientation of a genomic region containing dosage-sensitive ...
On the Epistemological Crisis i ...
There is an epistemological crisis in genomics. At issue is what constitutes scientific knowledge in genomic science, or systems biology in general. ...
Understanding Genetic Factors i ...
Idiopathic scoliosis (AIS) is the most common pediatric spinal deformity, affecting ~3% of children worldwide. AIS significantly impacts national hea ...
Meta Analysis of Gene Expressio ...
Since the second half of the 1990s, a large number of genome-wide analyses have been described that study gene expression at the transcript level. To ...
Molecular Cytogenetics and Cyto ...
Molecular cytogenetics is a promising field of biomedical research that has recently revolutionized our thinking on genome structure and behavior. Th ...