Pas de deux: Natural Killer Rec ...
Major histocompatibility complex (MHC) class I and NK cell receptor gene regions are a paradigm of genomic plasticity as they reveal a considerable d ...
Zebrafish as a Model System to ...
Zebrafish (Danio rerio) is a bona fide vertebrate model system for understanding human diseases. It allows the transparent visualization of the effec ...
Megsin Gene: Its Genomic Analys ...
It is critical to uncover genes specifically expressed in individual cell types for further understanding of cell biology and pathology. In order to ...
Genetic and Environmental Facto ...
Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addic ...
Myostatin in the Pathophysiolog ...
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved acr ...
H2A.Z-Mediated Genome-Wide Chro ...
The characterization of the involvement of different histone post-translational modifications (PTMs) and histone variants in chromatin structure has ...
Recent Computational Approaches ...
This paper reviews recent computational approaches to the understanding of gene regulation in eukaryotes. Cis-regulation of gene expression by the bi ...
Gene Expression Profiling and i ...
The availability of sequenced genomes of human and many experimental animals necessitated the development of new technologies and powerful computatio ...
Cautionary Tail: The Presence o ...
As part of structural investigations of components of the molecular motor, dynein, we prepared the light chain, Robl1_mouse, with and without an N-te ...
Parallel Gene Expression Profil ...
DNA microarray technology has been a valuable tool to provide a global view of the changes in gene expression that characterize different types of B ...
Longevity Genomics Across Speci ...
Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determin ...
Current Therapeutic Options for ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the developed world. The increasing life expectancy in the last years has le ...
Gene Expression Studies in Mult ...
Abstract: Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 ...
The Human Pseudoautosomal Regio ...
The pseudoautosomal regions (PAR1 and PAR2) of the human X and Y chromosomes pair and recombine during meiosis. Thus genes in this region are not inh ...
Role of Insulin and Growth Horm ...
Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling pathways involved in the control of lifespans in lower org ...
Ribosomal Proteins and Colorect ...
The ribosome is essential for protein synthesis. The composition and structure of ribosomes from several organisms have been determined, and it is we ...
The MDM2 Ubiquitination Signal ...
Genetic and biochemical studies have shown that Ser20 phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DNA-dependent p53 ...
Ovarian Cancer Biomarkers: A Fo ...
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease- ...
Incomplete Coverage of Candidat ...
Current genetic investigations are performed both on the basis of a rational and biologically based choice of candidate genes and through genome wide ...
Characteristics of Human and Mo ...
Characteristics of human and mouse orthologous gene sequences which have large G+C content variations were investigated in this study. The orthologou ...
The Development of Chromosome M ...
The technique of chromosome microdissection and microcloning has been developed for more than 20 years. As a bridge between cytogenetics and molecula ...
Enjoy the Silence: The Story of ...
Cancer is a multi-step disease involving dynamic changes in the genome. However, studies on cancer genome so far have focused most heavily on protein ...
Comparison of meshes, gels and ...
Full-thickness articular cartilage defects lack the capacity of healing because of lack of blood supply and lack of chondrocyte proliferation around ...
Long-term results of craniofaci ...
A variety of materials are currently implanted in the reconstruction of bony defects of the cranial vault. Traditionally, autologous bone demonstrat ...
Use of statins for enhancing bo ...
Bone tissue engineering is a potential emerging therapy for patients suffering from bone loss as a result of trauma or disease. Statins are a common ...