Intradialytic hypotension
Defining and redefining the nep ...
It has long been appreciated that the mammalian kidney arises via reciprocal interactions between an epithelial ureteric epithelium and the surround ...
A 10-year-old boy with dark uri ...
Mitochondrial fatty acid â-oxidation (FAO) is essential for energy homeostasis in skeletal muscle under conditions that require simultaneous glucose ...
Fetal environment, epigenetics, ...
The notion that some adult diseases may have their origins in utero has recently captured scientists’ attention. Some of these effects persist acros ...
Abdominal pain in a female adol ...
Differential diagnosis of abdominal pain in a female teenager with autosomal dominant polycystic kidney disease (ADPKD) and insulin-dependent diabet ...
Microvascular disease in childr ...
The incidence of type 1 diabetes (T1D) is increasing worldwide and is associated with a significant burden, mainly related to the development of vas ...
aHUS caused by complement dysre ...
Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disease that is caused by defective complement regulation in over 50% of cases. Mutatio ...
Patterning and early cell linea ...
Specification of the intermediate mesoderm and the epithelial derivatives that will make the mammalian kidney depends on the concerted action of man ...
TRPC channel modulation in podo ...
Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. ...
New therapies in steroid-sensit ...
Although many children with idiopathic nephrotic syndrome (INS) respond initially to steroid therapy, repeated courses for patients with relapses of ...
Dent’s disease: clinical featur ...
Dent’s disease is an X-linked recessive renal tubulopathy characterized by low-molecular-weight proteinuria (LMWP), hypercalciuria, nephrocalcinosis ...
Abdominal pain in a female adol ...
A 16-year-old white female presented to the emergency department (ED) with complaints of multiple episodes of vomiting, colicky left flank, and lowe ...
Genetics of congenital anomalie ...
Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 1 in 500 births and are a major cause of morbidity in children. Notably, CAKUT ...
Cystinosis: practical tools for ...
Cystinosis is the major cause of inherited Fanconi syndrome, and should be suspected in young children with failure to thrive and signs of renal pro ...
Biomarkers of acute kidney inju ...
Acute kidney injury (AKI) in children is associated with increased mortality and prolonged length of hospital stay and may also be associated with l ...
Renal amyloidosis in children
Renal amyloidosis is a detrimental disease caused by the deposition of amyloid fibrils. A child with renal amyloidosis may present with proteinuria ...
Ciliopathies: an expanding dise ...
Ciliopathies comprise a group of disorders associated with genetic mutations encoding defective proteins, which result in either abnormal formation ...
Intradialytic hypotension
Intradialytic hypotension (IDH) is common in children during conventional, 4 hour haemodialysis (HD) sessions. The declining blood pressure (BP) was ...
Diagnosis and management of chi ...
A number of syndromic disorders have renal cysts as a component of their phenotypes. These disorders can generally be distinguished from autosomal d ...
Management of toxic ingestions ...
Although rare, renal replacement therapy (RRT) for the treatment of the metabolic, respiratory and hemodynamic complications of intoxications may be ...
PPARم and chronic kidney diseas ...
Peroxisome proliferator-activated receptor-م (PPARم) agonists, exemplified by the thiazolidinediones (TZDs), have been used extensively for their be ...
Parathyroid hormone and growth ...
Growth failure is common in children with chronic kidney disease, and successful treatment is a major challenge in the management of these children. ...
Consequences and therapy of the ...
Metabolic acidosis is common in patients with chronic kidney disease (CKD), particularly once the glomerular filtration rate (GFR) falls below 25 ml ...
Role of fibroblast growth facto ...
Fibroblast growth factor receptors (Fgfrs) are expressed throughout the developing kidney. Several early studies have shown that exogenous fibroblas ...
Nocturnal enuresis—theoretic ba ...
Nocturnal polyuria, nocturnal detrusor overactivity and high arousal thresholds are central in the pathogenesis of enuresis. An underlying mechanism ...
Heat shock proteins in chronic ...
Heat shock proteins (HSP) form a heterogenous, evolutionarily conserved group of molecules with high sequence homology. They mainly act as intracell ...