Combination HIV Prevention: Significance, Challenges, a ...
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Point-of-Care Testing
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Combination HIV Prevention: Sig ...
No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in p ...
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Pathogenesis of HIV in the Cent ...
HIV can infect the brain and impair central nervous system (CNS) function. Combination antiretroviral therapy (cART) has not eradicated CNS complica ...
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Coreceptors and HIV-1 Pathogene ...
The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Al ...
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Point-of-Care Testing
The availability of rapid, point-of-care (POC) tests has significantly expanded the capacity of both developed and resource-constrained countries (R ...
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Alterations of the B-Cell Respo ...
While the hallmark of HIV-1 infection is the progressive depletion of CD4+ T cells, extensive B-cell dysfunction ensues that impairs the quality of ...
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Revisiting Immune Exhaustion Du ...
Chronic immune activation is a hallmark of HIV infection, yet the underlying triggers of immune activation remain unclear. Persistent antigenic stim ...
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IL28B Polymorphisms and Treatme ...
Recently, single-nucleotide polymorphisms near the IL28B gene have been identified as important in predicting treatment response and spontaneous cle ...
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Rational Guide to the Use of Er ...
Hepatitis C virus (HCV) infection is the leading reason for liver transplant in North America. Combination therapy with pegylated interferon and ri ...
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Management of Hepatitis C Antiv ...
Hepatitis C is one of the leading causes of liver disease in the United States, affecting more than 4 million individuals. The current treatment reg ...
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HCV Eradication: Implications f ...
Hepatitis C virus (HCV) is a leading cause of liver-related death worldwide. The evolution of hepatitis C therapy has made serologic eradication of ...
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Update on Current Epidemiologic ...
Hepatitis C virus infection remains a leading cause of liver disease worldwide and is currently the principal reason for liver transplantation in th ...
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Extrahepatic Manifestations of ...
Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is a leading cause of chronic liver disease worldwide. Ext ...
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HCV Response-Guided Therapy: Sh ...
The treatment of chronic HCV has traditionally been for a fixed duration based on genotype. We now recognize that patients respond to treatment alon ...
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The Emerging Role of Histone De ...
T-cell lymphomas are an uncommon and heterogeneous group of non-Hodgkin lymphomas. Historically, therapies for these diseases have been borrowed fro ...
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Burkitt Lymphoma and Atypical B ...
Burkitt lymphoma (BL) is a mature B-cell non- Hodgkin lymphoma with an aggressive clinical course. Since the advent of short, intensive, multiagent ...
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The Role of Transplantation in ...
Rituximab has improved the prognosis of patients with diffuse large B-cell lymphoma, but a high proportion of patients with advanced disease will re ...
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New Immunomodulatory Drugs in M ...
Multiple myeloma (MM) is an incurable malignancy of plasma cells. The introduction of thalidomide was a milestone in the treatment of MM. Thalidomid ...
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Special Issues in Myeloprolifer ...
Special issues in myeloproliferative neoplasms (MPN) comprise clinical conditions with high relevance for the duration and quality of the patient’s ...
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Future Therapies for the Myelop ...
Ever since their description as “myeloproliferative syndromes” by William Dameshek in 1951, the myeloproliferative neoplasms (MPNs) have been manage ...
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The Search for Better Prognosti ...
Myelodysplastic syndromes (MDS) are a group of heterogeneous bone marrow disorders characterized by a failure of hematopoiesis and an increased prop ...
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Therapeutic Modalities for Pati ...
The treatment of myelodysplastic syndromes (MDS) involves a complex algorithm that depends on multiple factors, including symptoms, performance stat ...
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Recognition and Management of S ...
It is increasingly recognized that sleep-disordered breathing (SDB) is a common modifiable risk factor for cardiovascular disease with significant i ...
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Controversies in Cardiac Resync ...
Cardiac resynchronization therapy (CRT) is well established in the treatment of patients with heart failure, but lacks data addressing sex differenc ...
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Mechanical Bridge to Decision: ...
While great strides have been made in the management of heart failure syndromes, acute refractory cardiogenic shock carries a dismal prognosis. Init ...
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Targeting Hyponatremia and Hemo ...
Current treatment of acute decompensated heart failure (ADHF) has not reduced the significant morbidity or mortality associated with this disease, a ...
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