Leukemia stem cells
Additional erythrocytic and ret ...
Hereditary spherocytosis (HS) is characterised by weakened vertical linkages between the membrane skeleton and the red blood cell’s lipid bilayer, l ...
Contribution of VKORC1 and CYP2 ...
Within the Asian populations, Indian patients had been reported to require higher warfarin dose compared with the Chinese and Malay patients, and th ...
Impact of cytokine gene polymor ...
Autoreactive cytotoxic T cells play a key role in the pathogenesis of aplastic anemia (AA) by myelosuppressive cytokines including interferon-gamma, ...
The role of zinc protoporphyrin ...
The differentiation between primary myelofibrosis (PMF) and essential thrombocythaemia (ET) may be difficult especially in early-stage disease. In P ...
Leukemias induced by altered TR ...
Rapamycin is a potent allosteric mTORC1 inhibitor with clinical applications as an anticancer agent. However, only a fraction of cancer patients res ...
Molecular characterization of a ...
Over 80% of the α-thalassemia cases in southern China are caused by large deletions involving the α-globin gene cluster on chromosome 16p13.3. Here, ...
Cost-effectiveness of adenotons ...
In children with sickle cell disease (SCD), adenotonsillar hypertrophy or recurrent tonsillitis are frequently linked with an increased risk of obst ...
A prospective study to assess t ...
This prospective study was carried out to assess the usefulness of five laboratory tests in the diagnosis of hereditary spherocytosis (HS), based on ...
Oxidative stress contributes to ...
In the present study, we questioned the role of oxidative stress in hereditary spherocytosis (HS), where red blood cells (RBC) have a shortened surv ...
Hydralazine and magnesium valpr ...
Decitabine and azacitidine, two DNA methyltransferase (DNMT) inhibitors, are the current standard of treatment for myelodysplastic syndrome (MDS). H ...
Myeloid growth factors in acute ...
Randomized controlled trials (RCT) investigating administration of colony-stimulating factors (CSF) during or after chemotherapy in acute myeloid le ...
Dysmetabolic hyperferritinemia ...
Hyperferritinemia is common in individuals with the metabolic syndrome (dysmetabolic hyperferritinemia), but its pathophysiology and the degree to w ...
Deferasirox effectively decreas ...
Iron overload is present in several cases of double heterozygous sickle-cell/beta-thalassemia (HbS/β-thal). Deferasirox is an orally administered ir ...
Quantitative analysis of Hb Bar ...
It has long been recognized that the presence of hemoglobin (Hb) Bart’s in newborn’s blood is associated with α-thalassemia. However, the automated ...
Expansion of CD4+CD25+ regulato ...
Rapamycin has important roles in the modulation of regulatory T cells. We tried to expand CD4+CD25+ regulatory T cells (Treg cells) from umbilical c ...
Leukemia stem cells
Leukemia-initiating cells (LICs) or leukemia stem cells (LSCs) are defined by their ability to form tumors after xenotransplantation in immunodefici ...
Iron overload in MDS—pathophysi ...
Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerba ...
Proliferation and differentiati ...
CD34 is the most frequently used marker for the selection of cells for bone marrow (BM) transplantation. The use of CD133 as an alternative marker i ...
Variant of the extensor pollici ...
Variations on muscular and tendinous connections of the hand occur frequently in the human population and are often discovered during routine surgic ...
A case of double aortic arch ac ...
During the elective course of human dissection at the University of Toyama in 2007, we encountered a rare case of double aortic arch accompanied by ...
A case of anomalous bronchial a ...
There have been no anatomical reports on the origin of the bronchial artery derived from the coronary artery. In a 2006 cadaveric dissection course, ...
Bone growth and sexual dimorphi ...
This paper addresses the effect of a reduction of uterine blood flow (RUB) on postcranial bone growth in rats. The objectives were: (1) to discover ...
The fibrillar organisation of t ...
The collagen architecture of secondary osteons was studied with scanning electron microscopy (SEM) employing the fractured cortex technique and osmi ...
A schematic diagram showing the ...
A retroesophageal right subclavian artery, arising from the arch of the aorta as the terminal branch and passing dorsal to the esophagus, was found ...
The superficial brachial artery ...
The human superficial brachial artery passes superficially to the median nerve and can be classified into three subtypes according to its topographi ...