High levels of microRNA-21 in the stroma of colorectal ...
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High levels of microRNA-21 in t ...
Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 ...
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Improvements in population-base ...
We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primar ...
235.45 KB
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Loss of one Tgfbr2 allele in fi ...
Accumulation of fibroblasts is a phenomenon that significantly correlates with formation of aggressive cancers. While studies have shown that the TG ...
1.10 MB
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Gli1 enhances migration and inv ...
Gli1 is an established oncogene and its expression in Estrogen Receptor (ER) a negative and triple negative breast cancers is predictive of a poor p ...
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Proteomic profiling of lipid ra ...
Tumor biomarkers assist in the early detection of cancer, act as therapeutic targets for intervention, and function as diagnostic indicators for the ...
984.97 KB
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Transcriptional silencing of N- ...
N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. ...
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Is gastrointestinal dysfunction ...
Although impaired gastrointestinal motility from gastric cancer peritoneal metastasis (GCPM) causes extraordinary pain, its cause is unclear. Inters ...
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Transient silencing of galectin ...
Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcita ...
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Endoglin suppresses human prost ...
Endoglin is a transmembrane receptor that suppresses human prostate cancer (PCa) cell invasion. Small molecule therapeutics now being tested in huma ...
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Deletion of galectin-3 in the h ...
Galectin-3, a b galactoside–binding lectin, plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation ...
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RGS22, a novel cancer/testis an ...
RGS22 is a novel testis specific gene. It is located within chromosome 8q22.2, which shows high relevance with tumor chromosomal aberrations. We in ...
1.01 MB
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A systems view of epithelial–me ...
Epithelial–mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancers. While considerable ...
1.14 MB
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IFN-c is essential for the inhi ...
We previously found that chronic alcohol consumption (20% w/v in drinking water) that models the level consumed by human alcoholics, when administer ...
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Effect of zoledronic acid and a ...
Osteosarcoma (OSA) is an aggressive, highly metastatic and lytic primary bone neoplasm commonly affecting the appendicular skeleton of dogs and chil ...
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Role of DDR1 in the gelatinases ...
Discoidin domain receptors (DDRs) are receptor tyrosine kinases that get activated by collagens in its native triple-helical form. In mammalian cell ...
590.35 KB
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Differential expression of FAK ...
The murine EL4 lymphoma cell line exists in variants that are either sensitive or resistant to phorbol 12-myristate 13-acetate (PMA). In sensitive c ...
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Prognostic significance of clau ...
Adherent and tight junction molecules have been described to contribute to carcinogenesis and tumor progression. Additionally, the group of claudin- ...
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The synthetic triterpenoid CDDO ...
Survival following diagnosis of liver metastasis remains poor and improved treatment strategies to combat liver metastases are needed. Synthetic tri ...
532.05 KB
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c-Crk proto-oncogene contribute ...
As a member of adherens junction, p120-catenin (p120ctn) plays a major role in cell adhesions through stabilization of E-cadherin. p120ctn is transc ...
1.19 MB
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Impact of combined HDAC and mTO ...
The concept of molecular tumor targeting might provide new hope in the treatment of advanced prostate cancer. We evaluated metastasis blocking prope ...
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Fibroblast activation protein-a ...
Fibroblast activation protein-a (FAP) is a cell surface, serine protease of the post-prolyl peptidase family that is expressed in human breast cance ...
679.13 KB
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Differential expression of tart ...
Tartrate-resistant acid phosphatase (TRAP) exists in human serum as two major isoforms, monomeric 5a and proteolytically processed enzymatically act ...
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Alterations of the retinoblasto ...
Germline mutations affecting the retinoblastoma gene (RB1) predispose to inherited retinoblastomas but also other malignancies, including breast can ...
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Treatment outcome and prognosti ...
We retrospectively analyzed treatment outcomes and factors for poor prognosis for patients with renal cell cancer (RCC) bonemetastases. Patients wit ...
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Molecular alterations as target ...
Treating metastatic osteosarcoma (OS) remains a challenge in oncology. Current treatment strategies target the primary tumour rather than metastases ...
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