Drug-Binding Databases
Gene Expression Studies in Mult ...
Abstract: Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 ...
The Role of Androgen Receptor M ...
Prostate tumour growth is almost always dependent upon the androgen receptor pathway and hence therapies aimed at blocking this signalling axis are u ...
INVESTIGATION OF DEEP STERNAL W ...
Objective: To investigate factors that predict sternal wound complications in patients after coronary artery bypass grafting (CABG) because predictio ...
Estrogen Signaling Multiple Pat ...
Steroid hormones exert profound effects on cell growth, development, differentiation, and homeostasis. Their effects are mediated through specific in ...
5'–3'-UTR interactions regulate ...
Optimal induction of p53 protein after DNA damage requires RPL26-mediated increases in p53 mRNA translation. We report here the existence of a dsRNA ...
EGFR Intron Recombination in Hu ...
The epidermal growth factor receptor (EGFR) is a membrane-bound, 170 kDa, protein tyrosine kinase that plays an important role in tumorigenesis. The ...
Myotonic Dystrophies 1 and 2: C ...
Two multi-system disorders, Myotonic Dystrophies type 1 and type 2 (DM1 and DM2), are complex neuromuscular diseases caused by an accumulation of exp ...
Pharmacogenomics of Human ABC T ...
Some genetic polymorphisms of human ABC transporter genes are reportedly related to the risk of certain diseases and patients’ responses to medicatio ...
Expression and Function of Krup ...
Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiatio ...
Mechanisms Used by Human Papill ...
The greatest risk factor for the development of cervical and other cancers that have been linked to the human papillomavirus (HPV) family is the pers ...
The Story of SPATA2 (Spermatoge ...
In an attempt to isolate new spermatogenesis-associated genes, pd1 was initially identified and cloned as a novel human cDNA sequence from testis cDN ...
Nutrigenomic Analysis of Diet-G ...
Recent advances in molecular biology combined with the wealth of information generated by the Human Genome Project have fostered the emergence of nut ...
Immunological Aspects of Adult ...
Adult T-cell leukemia/lymphoma (ATLL) is a distinct disease caused by the first discovered human oncogenic retrovirus, human T-cell leukemia virus ty ...
Computational Approaches for Pr ...
A central focus of cancer genetics is the study of mutations that are causally implicated in tumorigenesis. Although missense variants are commonly i ...
Assessment of Different Express ...
The ability of plants to serve as a production system for bacterial lipoprotein vaccines has been investigated. First, the effect of high-level expre ...
NS3 Helicases as Drug Targets
Members of the viral family Flaviviridae are a major cause of infectious diseases, such as hepatitis C, Dengue fever, Japanese encephalitis, Yellow f ...
Drug-Binding Databases
Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. Th ...
Immune Mechanisms and Novel Pha ...
Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and both innate and adaptive immunity contribute to the pathogenesis. ...
Intercalation of Erlotinib and ...
Both the multi-targeted antifolate pemetrexed and the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib have establis ...
NPY Signalling Pathway in Bone ...
Neuropeptide (NPY) is a neurotransmitter widely distributed in central and peripheral nervous system that has been implicated in several physiologica ...
Pathophysiology of Sepsis in th ...
The aging world population will increase the incidence and mortality of severe sepsis. The aim of the present article is to review the pathophysiolog ...
p53 mediates the negative regul ...
MDM2 is an oncoprotein whose transforming potential is activated by overexpression. The expression level of MDM2 is negatively regulated by orphan r ...
Database resources of the Natio ...
In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis ...
Future of cord blood for non-on ...
For the last 5 years cord blood (CB) has been under intense experimental investigation in in vitro differentiation models and in preclinical animal ...
The disease progression associa ...
Arenaviruses are negative strand RNA viruses that can cause disease and hemorrhagic fever in humans. Typically, research with the hemorrhagic fever c ...