The b2-adrenergic receptor and Her2 comprise a positive ...
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The b2-adrenergic receptor and ...
In this study, b2-AR level was found to be up-regulated in MCF-7 cells overexpressing Her2 (MCF-7/ Her2). Correlation of b2-AR level with Her2 statu ...
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Amplification of ESR1 may predi ...
The estrogen receptor (ER) is the target of tamoxifen, but endocrine therapies do not benefit all patients with ER positive tumors. We therefore hyp ...
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Detection of circulating tumor ...
Most assays to detect circulating tumor cells (CTCs) rely on EpCAM expression on tumor cells. Recently, our group reported that in contrast to other ...
610.66 KB
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CD36-mediated activation of end ...
Thus far the clinical benefits seen in breast cancer patients treated with drugs targeting the vascular endothelial growth factor (VEGF) pathway are ...
369.75 KB
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Amplification of the prolactin ...
The identification of lobular carcinoma in situ (LCIS) in a patient’s specimen confers an appreciable increased risk of development of future invasi ...
1.13 MB
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Overexpression of HER2 signalin ...
The final signal for triggering the formation of lamellipodia that initiate directional migration of mammalian cells is binding of the Wiskott–Aldri ...
825.69 KB
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Triple negative breast cancer: ...
Triple negative breast cancer (TNBC) is an aggressive clinical phenotype characterized by lack of expression (or minimal expression) of estrogen rec ...
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Ionizing radiation or mitomycin ...
BRCA1 and BRCA2 genes are essential in preserving the integrity of genome, and it is not unambiguously clear whether the heterozygosity status may a ...
299.63 KB
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Involvement of PKC delta (PKCd) ...
Doxorubicin is an anti-tumor antibiotic widely used in the management of cancer patients. Its main mechanism of action involves the generation of DN ...
459.14 KB
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Accumulation of mutations over ...
The occurrence of heteroplasmy and mixtures is technically challenging for the analysis of mitochondrial DNA. More than that, observed mutations nee ...
560.85 KB
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Large genomic rearrangements of ...
Germline mutations in BRCA1 and BRCA2 increase the risk for developing breast and ovarian cancer. Previously, the techniques available allowed only ...
582.68 KB
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The ErbB3 binding protein EBP1 ...
The ErbB2/3 heterodimer plays a critical role in breast cancer progression and in the development of endocrine resistance. EBP1, an ErbB3 binding pr ...
461.14 KB
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Immunoconjugated gold nanoshell ...
Trastuzumab is a FDA-approved drug that has shown clinical efficacy against HER2? breast cancers and is commonly used in combination with other chem ...
436.51 KB
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Effects of estrogen on the prop ...
There is increasing evidence that breast cancers contain tumor-initiating cells with stem cell properties. The importance of estrogen in the develop ...
819.91 KB
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Patterns and incidence of chrom ...
One of the hallmarks of human solid tumors is chromosomal instability (CIN). We studied global patterns as well as individual levels of CIN and dete ...
459.87 KB
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Endoscopic breast surgery: wher ...
Endoscopic surgery has been extensively used for many surgical conditions and has gained acceptance as an alternative and less invasive approach to ...
1.60 MB
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Are we missing the mTOR target ...
Abnormalities in the PI3K/Akt/mTOR intracellular signalling pathway have been implicated in several forms of human cancer. The central component of ...
125.72 KB
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Gene expression analysis reveal ...
Male breast cancer (MBC) is a poorly characterized disease because of its rarity. Clinical management is based on results obtained from randomized t ...
384.83 KB
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miR-17-5p promotes human breast ...
MicroRNAs have been implicated in regulating diverse cellular pathways. Emerging evidence indicate that the miR-17-92 cluster may have a causal role ...
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RERG (Ras-like, oestrogen-regul ...
Global gene expression profiling studies have classified breast cancer into a number of distinct biological and molecular classes with clinical rele ...
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Soy isoflavones consumption and ...
Numbers of epidemiologic studies assessing soy consumption and risk of breast cancer have yielded inconsistent results. We aimed to examine the asso ...
295.93 KB
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Platelet-derived growth factor- ...
Platelet-derived growth factor-D (PDGF-D) has been linked with several human malignancies; however, its role in breast cancer progression is not kno ...
597.90 KB
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Loss of ICAM-1 signaling induce ...
Psoriasin (S100A7), a member of the S100 gene family, is highly expressed in high-grade comedo ductal carcinoma in situ (DCIS), with a higher risk o ...
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‘‘Overcoming breast cancer drug ...
The mTOR pathway is pivotal not only in tumorigenesis but also in chemotherapy and hormonal drug sensitivity. It is clear that improvements in using ...
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MIB1/Ki-67 labelling index can ...
Histological grade is recognized as one of the strongest prognostic factors in operable breast cancer (BC). Although grade 1 and grade 3 tumours are ...
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