Identification of immunodominant HLA-B7-restricted CD8+ ...
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Identification of immunodominan ...
Mammaglobin-A (MGBA), a 10-kD protein, is over expressed in 80% of primary and metastatic human breast cancers. Breast cancer patients demonstrate h ...
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Prevalence of the variant allel ...
Recently, a variant allele in the 30UTR of the KRAS gene (rs61764370 T[G) was shown to be associated with an increased risk for developing non-small ...
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Tumor–stroma ratio in the prima ...
Stroma tissue surrounding cancer cells plays an important role in tumor development and behavior. In colorectal cancer, it has been found that the a ...
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International distribution and ...
The c.156_157insAlu BRCA2 mutation has so far only been reported in hereditary breast/ovarian cancer (HBOC) families of Portuguese origin. Since thi ...
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The rexinoid bexarotene repress ...
Bexarotene is an RXR-selective vitamin A analog that has been shown to prevent ER-negative mammary tumorigenesis in animal models. While investigati ...
دانلود 2
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Targeting mutant p53 protein an ...
Breast cancer progression depends upon the elaboration of a vasculature sufficient for the nourishment of the developing tumor. Breast tumor cells f ...
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Three-dimensional collagen repr ...
The behavior of breast epithelial cells is influenced by their microenvironment which includes stromal cells and extracellular matrix (ECM). During ...
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Oral fluoropyrimidine may augme ...
The present preclinical study was designed to evaluate a new combination therapy comprised of the aromatase inhibitor anastrozole (ANA) and the oral ...
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RAD51 135G>C does not modify ...
A single-nucleotide polymorphism (SNP) in the 50-untranslated region (UTR) of RAD51, 135G[C (rs1801320), was reported to be associated with an incre ...
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Nicotine-induced human breast c ...
Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholin ...
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Interactions between breast can ...
The preferential metastasis of breast cancer cells to bone is a complex set of events including homing and preferential growth which may include uni ...
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Let-7 family miRNAs regulate es ...
In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA ...
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Combined Src and ER blockade im ...
Antiestrogen therapies arrest susceptible estrogen receptor (ER)-positive breast cancers by increasing p27. Since Src phosphorylates p27 to promote ...
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COX2 expression in prognosis an ...
In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a ...
519.55 KB
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GRB7 protein over-expression an ...
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine ...
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The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
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High immunogenic potential of p ...
As pre-existent immunity might be a reflection of an emerging anticancer response, the demonstration of spontaneous T-cell responses against tumor a ...
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The liver receptor homolog-1 re ...
Estrogen receptor-a (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatm ...
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The anti-diabetic drug metformi ...
We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Hercept ...
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The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...
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Presence of Foxp3 expression in ...
The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of bre ...
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Dead-box or black-box: is DDX1 ...
In this issue of Breast Cancer Research and Treatment, Germain et al. evaluate the potential role of DEAD-box 1 (DDX1) as an independent marker of p ...
دانلود 1
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Inhibition of focal adhesion ki ...
Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquir ...
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Overexpression of the urokinase ...
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice ...
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Clinical significance of high f ...
Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including brea ...
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