Dual targeting of EphA2 and ER restores tamoxifen sensi ...
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Dual targeting of EphA2 and ER ...
Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a target for brea ...
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Decreased expression of EZH2 is ...
The purpose of this study is to investigate EZH2 in a large series of breast cancer patients for its prognostic and predictive value, and to evaluat ...
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Cacalol, a natural sesquiterpen ...
We previously isolated cacalol as a free radical- scavenging compound from Cacalia delphiniifolia which is a traditional Asian herbal plant and is b ...
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Classical membrane progesterone ...
In this article, we demonstrate the expression of functional progesterone binding sites at the cell membrane in murine mammary carcinomas that are s ...
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Role of ferritin alterations in ...
Breast cancer is the most common malignancy in women. Successful treatment of breast cancer relies on a better understanding of the molecular mechan ...
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Clinical significance of high f ...
Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including brea ...
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Overexpression of the urokinase ...
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice ...
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Inhibition of focal adhesion ki ...
Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquir ...
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Dead-box or black-box: is DDX1 ...
In this issue of Breast Cancer Research and Treatment, Germain et al. evaluate the potential role of DEAD-box 1 (DDX1) as an independent marker of p ...
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Presence of Foxp3 expression in ...
The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of bre ...
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The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...
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The anti-diabetic drug metformi ...
We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Hercept ...
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The liver receptor homolog-1 re ...
Estrogen receptor-a (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatm ...
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High immunogenic potential of p ...
As pre-existent immunity might be a reflection of an emerging anticancer response, the demonstration of spontaneous T-cell responses against tumor a ...
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The value of preoperative stagi ...
Little is known about the benefits of preoperative staging chest computed tomography (CT) in patients with asymptomatic breast cancer. We therefore ...
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The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
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GRB7 protein over-expression an ...
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine ...
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COX2 expression in prognosis an ...
In breast cancer, the prognostic impact of COX2 expression varies widely between studies. We examined the prognostic value of COX2 expression in a ...
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Combined Src and ER blockade im ...
Antiestrogen therapies arrest susceptible estrogen receptor (ER)-positive breast cancers by increasing p27. Since Src phosphorylates p27 to promote ...
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Let-7 family miRNAs regulate es ...
In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA ...
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Interactions between breast can ...
The preferential metastasis of breast cancer cells to bone is a complex set of events including homing and preferential growth which may include uni ...
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Nicotine-induced human breast c ...
Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholin ...
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Clinical application of shear w ...
Shear wave elastography (SWE) is an emerging technique which can obtain quantitative elasticity values in breast disease. We therefore evaluated the ...
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RAD51 135G>C does not modify ...
A single-nucleotide polymorphism (SNP) in the 50-untranslated region (UTR) of RAD51, 135G[C (rs1801320), was reported to be associated with an incre ...
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Oral fluoropyrimidine may augme ...
The present preclinical study was designed to evaluate a new combination therapy comprised of the aromatase inhibitor anastrozole (ANA) and the oral ...
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