GRB7 protein over-expression and clinical outcome in br ...
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GRB7 protein over-expression an ...
The growth factor receptor-bound protein-7 gene (GRB7) encodes a multi-domain signal transduction molecule. The purpose of this study was to examine ...
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The TGF-b/Smad pathway induces ...
Transforming growth factor-b (TGF-b) has opposing roles in breast cancer progression by acting as a tumor suppressor in the initial phase, but stimu ...
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High immunogenic potential of p ...
As pre-existent immunity might be a reflection of an emerging anticancer response, the demonstration of spontaneous T-cell responses against tumor a ...
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The liver receptor homolog-1 re ...
Estrogen receptor-a (ER) is expressed in the great majority of breast cancers, and the inhibition of ER action is a key part of breast cancer treatm ...
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The anti-diabetic drug metformi ...
We here demonstrate that the anti-diabetic drug metformin interacts synergistically with the anti-HER2 monoclonal antibody trastuzumab (Tzb; Hercept ...
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The benefits of discussing adju ...
Breast cancer patients must often decide between multiple adjuvant therapy options to prevent cancer recurrence. Standard practice, as implemented i ...
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Presence of Foxp3 expression in ...
The Forkhead Box Protein 3 is highly expressed not only in regulatory T cells, but also in tumor cells, acting as a transcriptional repressor of bre ...
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Dead-box or black-box: is DDX1 ...
In this issue of Breast Cancer Research and Treatment, Germain et al. evaluate the potential role of DEAD-box 1 (DDX1) as an independent marker of p ...
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Inhibition of focal adhesion ki ...
Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquir ...
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Overexpression of the urokinase ...
uPAR, the three-domain membrane receptor of the serine protease urokinase, plays a crucial role in tumor growth and metastasis. Several mRNA splice ...
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Clinical significance of high f ...
Increased expression and activation of focal adhesion kinase (FAK) was reported to be an unfavorable factor in various human cancers, including brea ...
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Role of ferritin alterations in ...
Breast cancer is the most common malignancy in women. Successful treatment of breast cancer relies on a better understanding of the molecular mechan ...
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Classical membrane progesterone ...
In this article, we demonstrate the expression of functional progesterone binding sites at the cell membrane in murine mammary carcinomas that are s ...
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Cacalol, a natural sesquiterpen ...
We previously isolated cacalol as a free radical- scavenging compound from Cacalia delphiniifolia which is a traditional Asian herbal plant and is b ...
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Decreased expression of EZH2 is ...
The purpose of this study is to investigate EZH2 in a large series of breast cancer patients for its prognostic and predictive value, and to evaluat ...
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Dual targeting of EphA2 and ER ...
Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a target for brea ...
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The management of ductal intrae ...
The management of ductal intraepithelial neoplasia (DIN) has substantially changed over the past 30 years, as its incidence has increased (from 2–3% ...
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Preclinical evaluation of nucle ...
Prevention and early detection of breast cancer are the major prophylactic measures taken to reduce the breast cancer related mortality and morbidit ...
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BRCA1 promoter methylation in p ...
BRCA1 promoter methylation reportedly plays an important part in the pathogenesis of human breast cancer. In the present study, we investigated whet ...
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Mutations and polymorphic BRCA ...
We previously showed that about 80% of breast cancer patients at high risk to carry mutation in BRCA genes presented at least one polymorphism in th ...
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Time to move forward from ‘‘fir ...
For clinicians, it has been clear for many years that breast cancer patients with the same clinical and pathological characteristics can have divers ...
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Microcephalin is a new novel pr ...
The authors have investigated the expression of the microcephalin (MCPH1) protein to evaluate its prognostic importance in breast cancer. Microcepha ...
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Pachymic acid impairs breast ca ...
Pachymic acid (PA), a lanostane-type triterpenoid derived from Poria cocos, possesses demonstrated anti-inflammatory and anti-cancer activities. Non ...
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Identification of genes associa ...
Here we evaluated the cytotoxic effects of a combination of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and taxanes in ...
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Uptake of 2-NBDG as a method to ...
This study quantifies uptake of a fluorescent glucose analog, (2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4- yl)amino)-2-deoxyglucose) (2-NBDG), in a large ...
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