Randomized, double-blind compar ...
Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in breast cancer. Indocyanine green (ICG) is ...
Significant changes in dietary ...
The diagnosis of cancer can motivate survivors to alter their lifestyle habits. Healthcare providers need to be aware of what changes patients are l ...
Improved survival of patients w ...
In this study, changes in prognosis for more than 8,000 patients with primary distant metastatic breast cancer were analyzed, using nation-wide data ...
Genetic variants in ultraconser ...
Ultraconserved elements (UCEs) are the most extreme representatives of conserved non-coding sequences. Recent studies have indicated thatUCEs are no ...
No evidence for an association ...
Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is ...
The impact of contralateral mas ...
Among women with breast cancer and a BRCA1 or BRCA2 mutation, the lifetime risk of breast cancer may be as high as 40%. Many physicians recommend p ...
Prediagnostic plasma enterolact ...
Experimental and epidemiological studies have suggested that the phytoestrogen enterolactone is associated to biological mechanisms that may have po ...
Estrogen and insulin-like growt ...
Although estrogen receptor alpha (ERa) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer ...
The prognostic role of circulat ...
The prognostic significance of circulating tumor cells (CTCs) in patients with breast cancer is controversial. We performed a meta-analysis of publi ...
Role of PTEN promoter methylati ...
Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of breast cancer. Here, we found that S-adenosylmethionine (SAM) and DNA m ...
Detection of aberrant promoter ...
Aberrant promoter methylation of genes is a common molecular event in breast cancer. Thus, DNA methylation analysis is expected to be a new tool for ...
Resveratrol suppresses growth o ...
Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types o ...
COX-2 expression predicts worse ...
Some previous studies have found worse prognosis among cyclooxygenase-2 (COX-2)-expressing breast cancers. Aspirin and NSAIDs inhibit COX-2. Three ...
Biopsy sampling of breast lesio ...
Needle biopsy is now the initial investigation of choice for the pre-operative diagnosis of breast lesions. This includes core needle biopsy (CNB) a ...
The role of topoisomerase IIa i ...
Topoisomerase IIa is not only a proliferation marker of tumor cells, but is also a target for anthracyclinebased chemotherapy. Both in vitro and in ...
Pathological characteristics of ...
The immunophenotype of BRCA-associated breast cancer has been studied in predominantly non-Hispanic whites (NHW). We evaluated the pathological char ...
CG0006, a novel histone deacety ...
We previously reported that CG0006, a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI), suppresses the growth of human cancer cells ...
Mitochondrial amplification sel ...
The metabolic phenotype of cancer, characterized by uncoupled mitochondrial respiration and increased mitochondrial oxidative stress, is an attracti ...
Targeting low molecular weight ...
Low molecular weight cyclin E (LMW-E) plays an important oncogenic role in breast cancer. LMWE, which is not found in normal tissue, can promote the ...
Evidence for a link between TNF ...
Intracellular signaling mediated by the receptor activator of nuclear factor-jB [Rank, encoded by the tumor necrosis factor receptor superfamily, me ...
Local anesthetics inhibit kines ...
Detached breast tumor cells produce dynamic microtubule protrusions that promote reattachment of cells and are termed tubulin microtentacles (McTNs) ...
Are symptomatic guidelines for ...
Oncologists recommend chemotherapy to postmenopausal women with adverse prognostic factors, but predictors of the benefit of chemotherapy are mainly ...
Primary systemic chemotherapy o ...
Primary systemic chemotherapy has become a standard of care for operable breast cancer patients who are candidates for adjuvant chemotherapy. Induct ...
Neoadjuvant endocrine therapy f ...
Patients with resectable, nonmetastatic (stage I–IIIA) breast cancer usually receive adjuvant (postoperative) systemic therapy to control micrometas ...
Squamous cell carcinoma of the ...
Squamous cell carcinoma (SCC) of the breast is comparatively rare. Because of the small number of investigations based on sufficient population size ...