A systems view of epithelial–me ...
Epithelial–mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancers. While considerable ...
Endoglin suppresses human prost ...
Endoglin is a transmembrane receptor that suppresses human prostate cancer (PCa) cell invasion. Small molecule therapeutics now being tested in huma ...
Transcriptional silencing of N- ...
N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. ...
High levels of microRNA-21 in t ...
Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 ...
Versican induces a pro-metastat ...
The assembly of pericellular matrix containing hyaluronan (HA) and versican has been shown to be a prerequisite for proliferation and migration of m ...
Interaction between lung cancer ...
The incidence of brain metastasis is increasing, however, little is known about molecular mechanism responsible for lung cancer-derived brain metast ...
Biomarkers of metastatic potent ...
Two-dimensional isoelectric focusing and gel electrophoresis followed by mass spectrometry were used to detect, measure, and identify changes in pro ...
Tissue inhibitor of metalloprot ...
The ‘‘protease web’’, representing the network of proteases, their inhibitors, and effector molecules, arises as a pivotal determinant of tissue hom ...
Tetraspanins and tumor progress ...
Transmembrane protein tetraspanins either promote or suppress tumor invasion and metastasis. Their effects on tumor progression depend on the multim ...
Platelet adhesion and fusion to ...
To investigate the relevant molecular mechanisms of platelet in promoting metastasis of tumor cell. The adhesion of fluorescence dye labeled-platele ...
Lymphocyte subpopulation and de ...
Patients with cancer show variable levels of immunosuppression at the time of the presentation, and cytotoxic antineoplastic therapy is the primary ...
SOX2 gene expression in normal ...
The SOX gene family encodes a large group of transcription factors that are strongly involved in the normal human development and malignancies. Huma ...
Effect of IL-1b and TNF-a polym ...
So far, a number of association studies have focused on the effect of polymorphisms in IL-1b and TNF-a genes on the susceptibility to gastric cancer ...
Single oligoarray-based detecti ...
The most important mutation associated with Multiple Endocrine Neoplasia type 2B (MEN 2B) is the change of thymine to cytosine in codon 918 of exon ...
Orbital pseudotumor in a child: ...
Orbital pseudotumor is a benign, idiopathic, non-infectious and non-neoplastic clinical syndrome characterized by the presence of an inflammatory ma ...
Vardenafil, an inhibitor of pho ...
Decreased production and/or impaired action of nitric oxide (NO) play a role in the pathogenesis of atherosclerotic cardiovascular disease and erect ...
Rapid and sensitive allele-spec ...
Point mutations in the kinase domain of BCRABL were described in 40–90% of patients with chronic myeloid leukemia (CML) resistant to Imatinib. We he ...
Hypocholesterolemia is associat ...
The oxidative stress levels in plasma and hemolysate and cholesterol levels in plasma of sickle cell anemia patients, carriers and controls were eva ...
Role of serum adiponectin level ...
Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis-C-related liv ...
Serum prealbumin (transthyretin ...
Low serum protein and albumin are considered to significantly associate with malnutrition, impaired functional status, poor outcome, and mortality. ...
Survivin -31C/G polymorphism an ...
Gastric cancer, despite its decline in incidence, remains a public health problem worldwide, especially in Brazil, where higher incidence indexes ar ...
Gene delivery of soluble vascul ...
Intra-plaque angiogenesis plays an important role in the development of atherosclerotic plaque. Vascular endothelial growth factor (VEGF) is a major ...
Anemia correction by erythropoi ...
Little is known about the effect of anemia correction with erythropoietin (EPO) on B-type natriuretic peptide (BNP) levels, NYHA class, and hospital ...
Complete correction of anemia b ...
Insulin resistance and anemia secondary to erythropoietin deficiency characterize patients with endstage kidney disease. In a cross-sectional analys ...
Wnt/beta-Catenin pathway in hum ...
Gliomas are the most common primary intracranial tumors. Understanding the molecular basis of gliomas’ progression is required to develop more effec ...