DEAD box 1: a novel and independent prognostic marker f ...
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DEAD box 1: a novel and indepen ...
Breast cancer is a heterogeneous disease characterized by diverse molecular signatures and a variable response to therapy. Clinical management of br ...
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Cytokeratin 5 positive cells re ...
A majority of breast cancers are estrogen receptor (ER) positive and have a luminal epithelial phenotype. However, these ER? tumors often contain h ...
704.28 KB
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Stimulation of retinoic acid-in ...
The sodium iodide symporter (NIS) mediates the active iodide uptake in the thyroid gland as well as lactating breast tissue. Recently, we reported s ...
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Gene expression profile predict ...
Prognosis of early beast cancer is heterogeneous. Today, no histoclinical or biological factor predictive for clinical outcome after adjuvant anthra ...
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Transient over-expression of es ...
Estrogen receptor-a (ERa) positive breast cancer frequently responds to inhibitors of ERa activity, such as tamoxifen, and/or to aromatase inhibitor ...
600.37 KB
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Functional implication of TRAIL ...
Recently, TRAIL function has been elucidated beyond its known classical role of mediating cellular homeostasis and immune surveillance against trans ...
599.91 KB
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Breast cancer prognostic marker ...
Historically, new prognostic markers for breast cancer were assessed separately and sequentially in a series of studies, often with considerable cos ...
222.68 KB
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Development of 95-gene classifi ...
Our aim was to develop an accurate diagnostic system using gene expression analysis by means of DNA microarray for prognosis of node-negative and es ...
501.78 KB
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Native MAG-1 antibody almost de ...
native form of mouse monoclonal IgG1 antibody called MAG-1, which recognizes an epitope on provasopressin, has been found to shrink and produce ext ...
371.71 KB
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Mediator of DNA damage checkpoi ...
The mediator of DNA damage checkpoint protein 1 (MDC1) regulates cell cycle checkpoints and recruits repair proteins to sites of double-stranded DNA ...
408.52 KB
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MPA-induced gene expression and ...
Over the past several years, we have been interested in understanding the mechanisms by which mammary carcinomas acquire hormone independence. We d ...
1.20 MB
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CTEN (C-terminal tensin-like), ...
C-terminal tensin-like (CTEN) gene is a member of the TENSIN gene family, involved in cell migration and localised at focal adhesion sites. This stu ...
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Biological and clinical implica ...
Nicastrin is an essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteol ...
1.26 MB
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MicroRNA-30c expression level i ...
MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression and which have been implicated in cancer. We evaluated whether five candida ...
312.59 KB
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High-resolution analyses of gen ...
The advent of high-throughput technologies in molecular biology has dramatically increased our understanding of breast cancer during the past decade ...
128.91 KB
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The PHSCN dendrimer as a more p ...
The a5b1 integrin fibronectin receptor is an attractive therapeutic target in breast cancer because it plays key roles in invasion and metastasis. W ...
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PALB2 analysis in BRCA2-like fa ...
BRCA2 and PALB2 function together in the Fanconi anemia (FA)–Breast Cancer (BRCA) pathway. Mono-allelic and bi-allelic BRCA2 and PALB2 mutation car ...
212.57 KB
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Trastuzumab-DM1 (T-DM1) retains ...
Trastuzumab (Herceptin) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab-DM1 (T-DM1, trastuzum ...
650.13 KB
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Hypermethylation of the progest ...
Most breast carcinomas that are estrogen receptor (ER) and progesterone receptor (PR) positive respond initially to an endocrine therapy, but over t ...
881.37 KB
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Ep-CAM RNA expression predicts ...
Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.We aimed to validate the in ...
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Elevated TRF2 in advanced breas ...
Telomere repeat binding factor 2 (TRF2) binds directly to telomeres and preserves the structural integrity of chromosome ends. In vitro models sugge ...
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Selective and effective killing ...
The cell surface receptor tissue factor (TF) is regarded as a common but specific target on angiogenic tumor vascular endothelial cells (VECs) and t ...
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Pathways mediating the effects ...
Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression. Clinically, there are still limit ...
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A systematic review of the rela ...
The estrogen signal is mediated by the estrogen receptor (ER). The specific role of ER-beta, a second ER, in breast carcinogenesis is not known. A n ...
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Estrogen levels act as a rheost ...
A large proportion of breast cancers expresses the estrogen receptor alpha (ERa) and are dependent on estrogens for their proliferation and survival ...
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