Comparison of the response of p ...
The response of primary human peripheral blood mononuclear phagocytes to challenge with polyethylene particles of known size and dose was evaluated. ...
Regulation of p53 Localization ...
The abundance and activity of p53 are regulated largely by ubiquitin ligases. Here we demonstrate a previously undisclosed regulation of p53 localiza ...
In vitro cytokine production by ...
The authors evaluated the ability of bone cement to modify the pro"le of pro-in#ammatory cytokines secreted by the immune cells. Peripheral blood mon ...
Cytokine release in mononuclear ...
The aim of this study was the evaluation of the release of bone-resorbing cytokines in peripheral blood mononuclear cells (PBMC) of patients with ase ...
Mathematical model of heat tran ...
We present a mathematical model that describes heat and mass transfer during solid-state fermentation (SSF) of Aspergillus oryzae in a well-mixed rot ...
Burned-Out Testicular Tumor:A C ...
Germ cell tumors constitute the majority of all testicular tumors, which are relatively rare overall and are mainly encountered in young adults and t ...
Genetic Manipulation to Identif ...
We have identified the bottleneck steps limiting expression of penicillin acylase (PAC) through comparison of the expression performance for various ...
Biodegradable laminar implants ...
Due to its short half-life, renal toxicity and necessity for daily subcutaneous injections, recombinant human growth hormone (rhGH) would best be adm ...
Factors a!ecting the degradatio ...
The purpose of this work was to study the degradation of poly(lactide-co-glycolide) (PLG) microspheres in vivo and in vitro. Degradation rate constan ...
study of the scale-up of revers ...
A general rate model for liquid chromatography which considers nonlinear isotherms and various mass transfer effects, including axial dispersion, int ...
Sustained delivery of human gro ...
Purpose: The purpose of this study was to evaluate the release of recombinant human growth hormone (rhGH) from a novel nonpolymeric sustained release ...
Synthesis, characterization and ...
A series of poly(D,L-lactic-co-glycolic acid) (PLGA):poly(ethyleneglycol) (PEG) di-block copolymers were synthesized by ring-opening polymerization o ...
Degradable dextran hydrogels: c ...
The preparation of protein-loaded degradable hydroxyethyl methacrylated dextran (dex-HEMA) hydrogels, cylindrical macroscopic gels as well as microsp ...
Effects of acrylic acid on prep ...
Dextran hydrogels were obtained by radical copolymerization of methacrylated dextran (MA-dextran) with acrylic acid (AAc) using ammonium peroxydisulf ...
Kinetic Model of in vivo Foldin ...
Aggregation of misfolded proteins can reduce the yield in recombinant protein production. The underlying complex processes are additionally influenc ...
Thrombotic Thrombocytopenic Pur ...
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening complication of gemcitabine treatment. Since the approval of this nucleoside ...
Influence of Scale-Up on the Qu ...
The aerobic fed-batch production of recombinant human growth hormone (rhGH) by Escherichia coli was studied. The goal was to determine the productio ...
Thermodynamic studies of pressu ...
and temperature at both low(19 bar) and high (318 bar) pressures using a homologous series of hydrophobic poly-l-phenylalanine (n = 2–7) as the model ...
The accuracy and precision of a ...
Recently, we developed a new method for measuring the thermodynamic stability of proteins. The method, termed Stability of Unpurified Proteins from R ...
Protein–polysaccharide interact ...
If the most important parameters affecting protein–polysaccharide interactions are now well documented, recent advances concern the structure-buildin ...
Polymer thermodynamics of adsor ...
Since proteins are polymers, their adsorption at interfaces should share some common features with polymers whose adsorption behavior is being rather ...
C omplex formation of a calcium ...
The elution of FLAG-fusions (an octapeptide with the sequence DYKDDDDK) from immobilized anti-FLAG antibody M1 cannot be explained by a switch of the ...
Modeling the protein partitioni ...
Aqueous polymer two-phase system provides a powerful method for separation and puri:cation of biomaterials. Among various factors, polymer concentrat ...
Interaction of Bovine Myelin Ba ...
Despite the essential role played by myelin basic protein (MBP) in stabilizing the multilamellar structure of the myelin membrane, attempts at decip ...
A theoretical analysis of the t ...
Although the denaturing of adsorbed proteins on biomaterials surfaces is believed to lead to adverse tissue reactions to implanted materials, very li ...