Poly(ADP-ribose) polymerase-1 m ...
Although poly(ADP-ribose) polymerase-1 (PARP1) inhibition is a recent promising therapy in breast cancer, PARP1 expression in this disease is not kn ...
A recombination-based method to ...
Many missense variants in BRCA1 are of unclear clinical significance. Functional and genetic approaches have been proposed for elucidating the clini ...
Gene expression array testing o ...
Archived formalin-fixed, paraffin embedded (FFPE) tissues constitute a vast, well-annotated, but underexploited resource for the molecular study of ...
A high prevalence of BRCA1 muta ...
The Bahamas is a group of islands in the Caribbean with a high incidence of early onset breast cancer. In isolated populations, the identification o ...
LFA-1 gene polymorphisms are as ...
The infiltrative duct carcinoma (IDC) is the most common malignant breast cancer in females and genetic factors appear to play a significant role in ...
No evidence for an association ...
Breast cancer represents a serious public health problem worldwide, for its high incidence, morbidity, mortality, and its high cost treatment. It is ...
Vitamin D threshold to prevent ...
Aromatase inhibitor (AI)-associated arthralgia limits adherence to therapy in breast cancer. The pathophysiology may involve vitamin D status. We wi ...
Individual responses to chemoth ...
Differences in redox homeostatic control between cancer patients may underlie predisposition to drug resistance and toxicities. To evaluate interind ...
No association of polymorphisms ...
The human homolog of the Drosophila Scribble (SCRIB) tumor suppressor gene encodes a protein that regulates apical-basolateral polarity in mammalian ...
Glutathione S-transferase P1 Il ...
Glutathione S-transferase P1 (GSTP1) is involved in a wide range of detoxifying reactions. Any alteration in the structure, function, or expression ...
Polymorphic variants in TSC1 an ...
TSC1 acts coordinately with TSC2 in a complex to inhibit mTOR, an emerging therapeutic target and known promoter of cell growth and cell cycle progr ...
Risk of aggressive breast cance ...
The high morbidity and aggressive behavior of breast cancer are associated with genetic variations. Single nucleotide polymorphisms (SNPs) in many g ...
Ductal carcinoma in situ: trend ...
To describe therapy and changes in therapy over time for women diagnosed with ductal carcinoma in situ (DCIS) and treated in the community setting. ...
Aromatase immunoreactivity is i ...
Mammographic breast density (MBD) is one of the strongest risk factors for breast cancer. Unfortunately, the biologic basis underlying this associat ...
The association between two pol ...
Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) ...
PALB2 mutations in German and R ...
Since germline mutations in the PALB2 (Partner and Localizer of BRCA2) gene have been identified as breast cancer (BC) susceptibility alleles, the g ...
The non-breast-cancer death rat ...
Non-breast-cancer deaths currently account for almost half of deaths among breast carcinoma patients in the 15 years following diagnosis. Understand ...
Lack of association between HER ...
Epidemiological studies have investigated the association between HER2 codon 655 polymorphism and breast cancer susceptibility. However, the results ...
No evidence for an association ...
ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorp ...
Association of a vascular endot ...
Published studies on the association between the vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism and breast cancer risk are inco ...
The CASP8 rs3834129 polymorphis ...
The rs3834129 polymorphism, in the promoter of CASP8 gene, has been recently reported as associated with breast cancer risk in the general populatio ...
Polymorphisms of the nuclear re ...
Organic anion transporter polypeptides (OATPs, SLCOs) are involved in the uptake of conjugates steroid hormones such as estrone-3-sulfate. It has be ...
Circulating levels of inflammat ...
Mammographic density is strongly associated with breast cancer risk. Inflammation is involved in breast carcinogenesis, perhaps through effects on m ...
Mutation analysis of BRIP1 in m ...
Breast cancer (BC) in men is rare compared with BC in women, but its incidence is increasing along with attention toward this uncommon disease. Alth ...
Risk of second breast cancer ac ...
A recent study reported an increased risk of contralateral estrogen-negative breast cancer after a first primary estrogen-negative breast cancer. Ou ...