سرطان های زنان و زایمان – علوم پایه، دیدگاه های بالینی و درمانی Gynecologic Cancers: Basic Sciences, Clinical and Therapeutic Perspectives

Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers. Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. ---- Contents: -- Preface -- 1 Role of BRCA1 in Breast Cancer Metastasis -- 2 Interplay of Epigenetics with Gynecological Cancer -- 3 Antiangiogenic Therapy in Epithelial Ovarian Cancer -- 4 Peritonectomy Procedures and HIPEC for Peritoneal Metastasis from Ovarian Cancer -- 5 Individualized Novel Therapies for Patients with Tumor Suppressor Genes BRCA1 and BRCA2 Mutated Epithelial Ovarian Cancer -- 6 Ovarian Cancer Research in the Post Genomic Era — Challenges and Opportunities -- 7 Analysing Molecular Mechanism Related to Therapy- Resistance in In-vitro Models of Ovarian Cancer -- 8 Recurrent Ovarian Cancer — Basic Knowledge, Current Management, and Future Directions -- 9 Management of Ovarian Cancer — Is There a Role for Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)? -- 10 Anti-Angiogenic and Anti-Cancer Effects by Targeting the Protein Kinase G Type-Iα (PKG-Iα) Signaling Pathway and its Downstream Effects on Expression of Inhibitor of Apoptosis Proteins, C-IAP1, Livin and Survivin -- 11 Cancer of the Vulva — A Review -- 12 Robotic Surgery in the Management of Endometrial Cancer -- 13 Cervical Cancer in Human Immunodeficiency Virus (HIV) Positive Patients -- 14 Sentinel Lymph Node Detection in Early Stage Cervical Cancer -- 15 Adenocarcinoma of the Endometrium — The Art of Its Diagnosis