Spectroscopic methods and analysis : NMR, mass spectrometry, and metalloprotein techniques

Preface ....................................................................................................................... v Contributors ............................................................................................................ ix PARTI. NMR SPECTROSCOPY CH. 1, Introduction to Nuclear Magnetic Resonance, Christopher Jones and Barbara Mulloy ......................................1.. CH. 2. Structural Studies of Proteins in Solution Using Proton Nuclear Magnetic Resonance, David Neuhaus and Philip A. Evans .............................................. 15 CH. 3. Peptide Structure Determination by NMR, Michael P. Williamson ..................................................................... 69 CH. 4. High-Resolution NMR of DNA and Drug-DNA Interactions, Jill Barber, Helen F. Cross, and John A. Parkinson .................... 87 CH. 5. Structural Characterization of the Carbohydrate Moieties of Glycoproteins by High-Resolution 'H-NMR Spectroscopy, Herman van Halbeek ..................................................................... 11 5 CH. 6. The Application of Nuclear Magnetic Resonance to Structural Studies of Poly saccharides, Christopher Jones and Barbara Mulloy .................................. 149 CH. 7. Dynamic and Exchange Processes in Macromolecules Studied by NMR Spectroscopy, Lu-Yun Lian ................................................................................... 169 PART1 1. MASSS PECTROMETRY CH. 8. Introduction to Mass Spectrometry, Robin Wait ...................................................................................... 191 CH. 9. Laser Desorption Ionization Mass Spectrometry of Bioorganic Molecules, Michael Karas and Ute Bahr ........................................................ 215 CH. 10. 252-Californium Plasma Desorption Time-of-Flight Mass Spectrometry of Peptides and Proteins, Peter Roepstorff .............................................................................. 229 CH. 1 1. Fast Atom Bombardment Mass Spectrometry of Peptides, Robin Wait ...................................................................................... 237 CH. 12. Tandem Mass Spectrometry, Catherine E. Costello ..................................................................... 285 uii Contents PART11 1. METALLOPROTTEEICNH NIQUES CH. 13. Mossbauer Spectroscopy, Dominic P. E. Dickson ...............................................................3..1..5 CH. 14. Electron Paramagnetic Resonance Spectroscopy of Metalloproteins, Richard Cammack .....................................................................3 27 CH. 15. Resonance Raman Spectroscopy of Metalloproteins Using CW Laser Excitation, Roman S. Czernuszewicz ............................................................... 345 CH. 16. The Application of X-Ray Absorption Spectroscopy to Characterize Metal Centers in Proteins, C. David Garner .............................................................................3 75 Index ...............................................................................................................3..9..1.. .