Morphological Response of the Pineal Gland of Old Animals to Melatonin Course Injection
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : G. I. GubinaVakulika, L. A. Bondarenkob, A. R. Gevorkyanb
- چاپ و سال / کشور: 2011
Description
Abstract—The effect of 10daylong evening melatonin injections in the physiological dose range on the mor phological state of the pineal gland was studied in old (18 to 20 months old) rat males of the Wistar population. It was shown with the use of nucleic acids histochemical staining that melatonin course injection into old rats caused dosedependant morphofunctional activation of pinealocytes that was accompanied by the increase in nuclei area, optical density of nuclei and cytoplasm. This fact was indicative of stimulation of epiphyseal hor mone production of both indole and polypeptidic nature. The use of melatonin in a dose of 0.05 mg/kg of body mass was accompanied by polyploidization of pinealocytes nuclei, and a dose of 0.50 mg/kg of body mass induced forced apoptosis.
ISSN 20790570, Advances in Gerontology, 2011, Vol. 1, No. 2, pp. 166–170. © Pleiades Publishing, Ltd., 2011. Original Russian Text © G.I. GubinaVakulik, L.A. Bondarenko, A.R. Gevorkyan, 2009, published in Uspekhi Gerontologii, 2009, Vol. 22, No. 4, pp. 626–630. Received February 12, 2009
