Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gaspard d’Assignies & Claude Kauffmann & Yvan Boulanger & Marc Bilodeau & Valérie Vilgrain & Gilles Soulez & An Tang
- چاپ و سال / کشور: 2010
Description
Objective The purpose of this study was to evaluate the ability of a whole liver volume (WLV) segmentation algorithm to measure fat fraction (FF). Methods Twenty consecutive patients with histologically proven fatty liver disease underwent dual-echo in-phase/ out-of-phase MRI and magnetic resonance spectroscopy (MRS) at 1.5 T. Two readers independently performed semiautomatic 3D liver segmentation on the out-of-phase sequences using an active contour model. FF was calculated for voxels, segments and WLV. Segmentation inter-observer reproducibility was assessed by intra-class correlation coefficient (ICC) for WLV and FF. Fat fraction correlation and agreement as determined by histology, MRS and MRI were determined. Results ICC was 0.999 (95% CI: 0.999-1, P<0.001) for WLV FF calculation and 0.996 (95% CI: 0.990–0.998, P<0.001) for whole liver volume calculations. Strong correlations were found between FF measured by histology, MRS and WLV-MRI. A Bland-Altman analysis showed a good agreement between FF measured by MRS and WLVMRI. No systematic variations of FF was found between segments when analyzed by ANOVA (F=1.78, P=0.096). Conclusion This study shows that a reproducible whole liver volume segmentation method to measure fat fraction can be performed. This strategy may be integrated to a “one-stop shop” protocol in liver surgery planning.
Eur Radiol (2011) 21:301–309 DOI 10.1007/s00330-010-1941-1 Received: 29 May 2010 / Revised: 25 July 2010 / Accepted: 12 August 2010 / Published online: 3 September 2010
