Tumour thickness in oral cancer using an intra-oral ultrasound pro
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Wouter L. Lodder, Hendrik J. Teertstra, Ing B. Tan, Frank A. Pameijer ,Michiel W. M. van den Brekel
- چاپ و سال / کشور: 2010
Description
Objectives To investigate tumour-thickness measurement with an intra-operative ultrasound (US) probe. Methods A retrospective data analysis was undertaken for a total of 65 patients with a T1-2 oral cavity cancer, who were seen at a tertiary referral centre between 2004 and 2010. The correspondence between tumour thickness measured by ultrasonography and histopathology was assessed by Pearsonپfs correlation coefficient, and also between tumour thickness and the development of neck metastasis. Results In 11 cases, intra-oral measurement was not optimal due to limited mouth opening (n=2) or impossibility to depict the lesion (n=9). Tumour thickness measured by US correlated well with histopathology (n=23, R=0.93). Tumour thickness of .7mm carries a risk of lymph node metastasis of 12%, whereas in tumours exceeding 7mm this risk is 57% (p=0.001). Twenty-five percent developed neck metastasis and 19% had local recurrence. Conclusion Tumour thickness is an important predictive marker for lymph node metastases. As such, it can help in decision-making with regard to management of the primary tumour and neck. Based upon our findings, a wait-and-see policy is only warranted for superficial lesions with tumour thickness of less than 7mm, but only if regular follow-up using US-guided aspiration of the neck is ensured.
Eur Radiol (2011) 21: 98–106 DOI 10.1007/s00330-010-1891-7 Received: 3 May 2010, Revised: 8 June 2010, Accepted: 20 June 2010, Published online: 3 August 2010
