Combined magnetic resonance imaging of deep venous thrombosis and pulmonary arteries after a single injection of a blood pool contrast agent
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andreas Hansch & Stefan Betge & Gunther Poehlmann & Steffi Neumann & Pascal Baltzer & Alexander Pfeil & Matthias Waginger & Joachim Boettcher & Werner
- چاپ و سال / کشور: 2010
Description
Objective Agreement rate between magnetic resonance imaging (MRI) and Doppler ultrasound (DUS) for the detection of deep vein thrombosis (DVT) in the lower extremities was attempted by using the intravascular MRI contrast agent gadofosveset trisodium. The potential of this method to detect pulmonary embolism (PE) was also evaluated. Material and Methods Forty-three consecutive inpatients with ultrasound-confirmed DVT but no clinical signs of PE were prospectively enrolled in this feasibility study. MRI was performed after a single injection of gadofosveset trisodium. The pulmonary arteries were imaged using a 3D Fast Low Angle Shot (FLASH) gradient recalled echo sequence. Additionally, pulmonary arteries, abdominal veins, pelvic and leg veins were imaged using a fatsuppressed 3D gradient echo Volume Interpolated Breathhold Examination (VIBE FS). Results Gadofosveset trisodium-enhanced MRI detected more thrombi in the pelvic region, upper leg and lower leg than the initial DUS. In addition, PE was detected in 16 of the 43 DVT patients (37%). Conclusion This study shows the feasibility of a combined protocol for the MRI diagnosis of DVT and PE using gadofosveset trisodium. This procedure is not only more sensitive in detecting DVT compared to standard DUS, but is also able to detect PE in asymptomatic patients.
Eur Radiol (2011) 21:318–325 DOI 10.1007/s00330-010-1918-0 Received: 1 March 2010 / Revised: 7 June 2010 / Accepted: 21 June 2010 / Published online: 9 August 2010
