Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Gregor Sommer & Markus Klarhِfer & Claudia Lenz & Klaus Scheffler & Georg Bongartz & Leopold Winter
- چاپ و سال / کشور: 2010
Description
Objective This study analyses the diagnostic potential of Diffusion-Weighted Imaging with Background Suppression (DWIBS) in the detection of focal bone marrow lesions from multiple myeloma. The signal and contrast properties of DWIBS are evaluated in correlation with the serum concentration of M-component (MC) and compared with established T1- and T2-weighted sequences. Methods Data from 103 consecutive studies in 81 patients are analysed retrospectively. Signal intensities and apparent Diffusion Coefficients (ADC) of 79 focal lesions in the lumbar spine or pelvis of 38 patients are determined and contrast-to-noise-ratio (CNR) is calculated. Data frompatients with low (<20 g/L) and high (>20 g/dL) MC are evaluated separately. Results Signal intensities of focal myeloma lesions on T2w-STIR vary significantly depending on the MC, which leads to a loss in CNR in patients with high MC. No signal variation is observed for T1w-TSE and DWIBS. The CNR values provided by DWIBS in patients with high MC are slightly higher than those of T2w-STIR. ADC values in patients with low MC are significantly higher than in patients with high MC. Conclusion Whole-body DWIBS has the potential to improve the conspicuity of focal myeloma lesions and provides additional biological information by ADC quantification.
Eur Radiol (2011) 21:857–862 DOI 10.1007/s00330-010-1950-0 Received: 19 July 2010 / Accepted: 13 August 2010 / Published online: 19 September 2010
