Fibroblast Growth Factor, A Review
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Grace C. Chibesakunda & Carolyn S. Brecklin
- چاپ و سال / کشور: 2010
Description
Historically, phosphate homeostasis has been considered the result of an interaction between the kidneys, the parathyroid glands and the bone as the target organ. The discovery of FGF-23 and Klotho has advanced our understanding of mineral and bone disorder in CKD. We now know the bone is an active endocrine organ secreting phosphatonins and interacting with other organs. It has led us to a new axis; the bone kidney axis with reciprocal regulation of FGF-23 production in the bone and 1, 25 di-hydroxycalciferol in the kidney. Our understanding of the pathogenesis of many diseases of the bone has also been greatly elucidated. There is enthusiasm and hope in future studies of FGF-23. Even skeptics would agree that it is not an innocent bystander in physiology or disease. For the nephrologists, the question which remains to be answered is whether FGF-23 is an ally or an assailant in CKD. The answer could bring with it possibilities of earlier detection of at risk patients and or FGF-23 as a possible therapeutic target.
Kidney (2010) 19:290–293 DOI 10.1007/s00596-010-0178-y Published online: 3 November 2010
