Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Elham Barkhordari 1, Ali Akbar Amirzargar 1, Naser Ebrahimi-Daryani 2, Mahdi Mahmoudi 1, Bita Ansaripour 1, Maryam Alighardashi 1, Hamid Reza Ahmadi-
- چاپ و سال / کشور: 2011
Description
Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. This study was performed to investigate the important role of interleukin-12 (IL-12) in intestinal inflammation. For this study seventy one patients with IBS and 140 controls were investigated. The allele and genotype frequencies of IL-12 C(-1188)A were determined using polymerase chain reaction with sequencespecific primers. The allele A was more common that the allele C in both groups of patients and controls. There was not any significant difference on IL- 12 alleles and genotypes between patients and controls. The AA genotype was the most common genotypes, which was seen in 57.4% of the patients and 51.4% of the controls (p=0.53). Although frequency of the CC genotype in the control group was lower than the patient group, this difference was not significant (5.7% vs. 11.5%, respectively, p=0.16). Considering the lack of association between IL-12 C(-1188)A polymorphism and IBS, this cytokine gene polymorphism may not have significant role in the pathophysiology of disease
Copyright © 2011, Avicenna Journal of Medical Biotechnology. All rights reserved. Vol. 3, No. 1, January-March 2011
