Protective Effects of Capparis zeylanica Linn. Leaf Extract on Gastric Lesions in Experimental Animals
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Karanayil R. Sini 1*, Barij N. Sinha 2 , and Aiyolu Rajasekaran 3
- چاپ و سال / کشور: 2011
Description
The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HClethanol induced ulcer and 83.78% inhibition in indomethacin induced ulcer.
Copyright © 2011, Avicenna Journal of Medical Biotechnology. All rights reserved. Vol. 3, No. 1, January-March 2011
