Interpretation of Genomic Data Questions and Answers
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Richard Simon, D.Sc. Biometric Research Branch National Cancer Institute
- چاپ و سال / کشور: 2010
Description
Using a question and answer format we try to describe important aspects of using genomic technologies in cancer research. The main challenges are not managing the mass of data, but rather the design, analysis and accurate reporting of studies that result in increased biological knowledge and medical utility. Many analysis issues address the use of expression microarrays, but are also applicable to other whole genome assays. Microarray based clinical investigations have generated both unrealistic hype and excessive skepticism. Genomic technologies are tremendously powerful and will play instrumental roles in elucidating the mechanisms of oncogenesis and in bringing on an era of predictive medicine in which treatments are tailored to individual tumors. Achieving these goals involves challenges in re-thinking many paradigms for the conduct of basic and clinical cancer research and paradigms for the organization of interdisciplinary collaboration.
Richard Simon, D.Sc. Chief, Biometric Research Branch National Cancer Institute 9000 Rockville Pike MSC 7434 Bethesda MD 20892-7434 301.496-0975 (tel) 301.402-0560 (fax) rsimon@nih.gov
