اثر متنوع از هیپوکسی در پیشرفت تومور ( مباحث جاری در میکروبیولوژی و ایمونولوژی ، جلد 345 ) Diverse Effects of Hypoxia on Tumor Progression (Current Topics in Microbiology and Immunology, Vol. 345)
- نوع فایل : کتاب
- زبان : انگلیسی
- نویسنده : M. Celeste Simon
- چاپ و سال / کشور: 2010
- شابک / ISBN : 9783642133282, 9783642133299, 3642133282
Description
Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration
